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Phase Ib study of pevonedistat, a NEDD8-activating enzyme inhibitor, in combination with docetaxel, carboplatin and paclitaxel, or gemcitabine, in patients with advanced solid tumors.
Lockhart, A Craig; Bauer, Todd M; Aggarwal, Charu; Lee, Carrie B; Harvey, R Donald; Cohen, Roger B; Sedarati, Farhad; Nip, Tsz Keung; Faessel, Hélène; Dash, Ajeeta B; Dezube, Bruce J; Faller, Douglas V; Dowlati, Afshin.
Afiliação
  • Lockhart AC; Division of Medical Oncology, University of Miami/Sylvester Comprehensive Cancer Center, 1120 NW 14th Street, Suite 650L, Miami, FL, USA. aclockhart@med.miami.edu.
  • Bauer TM; Drug Development, Sarah Cannon Research Institute/Tennessee Oncology PLLC., Nashville, TN, USA.
  • Aggarwal C; Division of Hematology-Oncology, Department of Medicine, Perelman Center for Advanced Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Lee CB; Division of Hematology and Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Harvey RD; Departments of Hematology and Medical Oncology and Pharmacology, Emory University School of Medicine, Winship Cancer Institute of Emory University, Atlanta, GA, USA.
  • Cohen RB; Department of Medicine, Perelman Center for Advanced Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Sedarati F; Oncology Clinical Research, Millennium Pharmaceuticals, Inc., Cambridge, MA, USA.
  • Nip TK; Biostatistics, Takeda Development Centre EU, London, UK.
  • Faessel H; Quantitative Clinical Pharmacology, Millennium Pharmaceuticals, Inc., Cambridge, MA, USA.
  • Dash AB; Translational and Biomarker Research, Millennium Pharmaceuticals, Inc., Cambridge, MA, USA.
  • Dezube BJ; Oncology Clinical Research, Millennium Pharmaceuticals, Inc., Cambridge, MA, USA.
  • Faller DV; Oncology Clinical Research, Millennium Pharmaceuticals, Inc., Cambridge, MA, USA.
  • Dowlati A; Department of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Invest New Drugs ; 37(1): 87-97, 2019 02.
Article em En | MEDLINE | ID: mdl-29781056
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Protocolos de Quimioterapia Combinada Antineoplásica / Proteína NEDD8 / Neoplasias Tipo de estudo: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Invest New Drugs Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Protocolos de Quimioterapia Combinada Antineoplásica / Proteína NEDD8 / Neoplasias Tipo de estudo: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Invest New Drugs Ano de publicação: 2019 Tipo de documento: Article