Second trimester serum cortisol and preterm birth: an analysis by timing and subtype.
J Perinatol
; 38(8): 973-981, 2018 08.
Article
em En
| MEDLINE
| ID: mdl-29795321
ABSTRACT
OBJECTIVE:
We hypothesized second trimester serum cortisol would be higher in spontaneous preterm births compared to provider-initiated (previously termed 'medically indicated') preterm births. STUDYDESIGN:
We used a nested case-control design with a sample of 993 women with live births. Cortisol was measured from serum samples collected as part of routine prenatal screening. We tested whether mean-adjusted cortisol fold-change differed by gestational age at delivery or preterm birth subtype using multivariable linear regression.RESULT:
An inverse association between cortisol and gestational age category (trend p = 0.09) was observed. Among deliveries prior to 37 weeks, the mean-adjusted cortisol fold-change values were highest for preterm premature rupture of the membranes (1.10), followed by premature labor (1.03) and provider-initiated preterm birth (1.01), although they did not differ statistically.CONCLUSION:
Cortisol continues to be of interest as a marker of future preterm birth. Augmentation with additional biomarkers should be explored.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Segundo Trimestre da Gravidez
/
Hidrocortisona
/
Nascimento Prematuro
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Pregnancy
País/Região como assunto:
America do norte
Idioma:
En
Revista:
J Perinatol
Ano de publicação:
2018
Tipo de documento:
Article