Prediction of histological grade of endometrial cancer by means of MRI.
Eur J Radiol
; 103: 44-50, 2018 Jun.
Article
em En
| MEDLINE
| ID: mdl-29803384
ABSTRACT
OBJECTIVES:
To evaluate the ability of MRI in predicting histological grade of endometrial cancer (EC).METHODS:
IRB-approved retrospective study; requirement for informed consent was waived. 90 patients with histologically proven EC who underwent preoperative MRI and surgery at our Institution between Sept2011 and Nov2016 were included. Myometrial invasion (>50%) was assessed. Neoplasm and uterus volumes were estimated according to the ellipsoid formula; neoplasm/uterus volume ratio (N/U) was calculated. ADC maps were generated and histogram analysis was performed using commercially available software. MRI parameters were compared with the definitive histological grade (G1â¯=â¯28 patients, G2â¯=â¯29, G3â¯=â¯33) using ANOVA and Tukey-Kramer tests.RESULTS:
Deep myometrial invasion was significantly more frequent in G2-G3 lesions than in G1 ones (pâ¯<â¯0,005). N/U ratio was significantly higher for high-grade neoplasms (mean 0,08 for G1, 0,16 for G2 and 0,21 in G3; Pâ¯=â¯0,002 for G1 vs. G2-G3); a cut off value of 0,13 enabled to distinguish G1 from G2-G3 lesions with 50% sensibility and 89% specificity. ADC values didn't show any statistically significant correlation with tumour grade.CONCLUSIONS:
N/U ratio >0.13 and deep myometrial invasion are significantly correlated with high grade EC, whereas ADC values are not useful for predicting EC grade.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imageamento por Ressonância Magnética
/
Neoplasias do Endométrio
Tipo de estudo:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
Eur J Radiol
Ano de publicação:
2018
Tipo de documento:
Article