Assessment of the antitumor activity of a cyclopalladated ferrocene compound assisted by a dual-targeting drug delivery system.
Chem Commun (Camb)
; 54(60): 8312-8315, 2018 Jul 24.
Article
em En
| MEDLINE
| ID: mdl-29868665
ABSTRACT
One cyclopalladated ferrocene compound CP was synthesized, which showed a good cell cytotoxicity. Assisted by a dual-targeting drug delivery system, the anticancer activity of CP to MDA-MB-468 remained unchanged, but the toxicity to non-tumorigenic cell line NIH3T3 was remarkably reduced. This provided a new path for the development of cyclopalladated ferrocene as an antitumor drug candidate.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
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Compostos Ferrosos
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Sistemas de Liberação de Medicamentos
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Beta-Ciclodextrinas
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Metalocenos
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Ácido Hialurônico
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Antineoplásicos
Limite:
Animals
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Humans
Idioma:
En
Revista:
Chem Commun (Camb)
Ano de publicação:
2018
Tipo de documento:
Article