The association between septicemia and the risk of multiple sclerosis: a nationwide register-based retrospective cohort study in Taiwan.
QJM
; 111(9): 605-611, 2018 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-29878253
ABSTRACT
BACKGROUND:
Multiple sclerosis (MS) is the most common inflammatory demyelinating disease of the central nervous system. Few studies focused on the relationship between septicemia and MS.AIM:
To evaluate the potential impact of septicemia on risk for MS.DESIGN:
Two cohorts of patients with septicemia and without septicemia were followed up for the occurrence of MS.METHODS:
Patients of 482 790 with septicemia was enrolled from the National Health Insurance Research Database between 2001 and 2011 as the study group to match the 1 892 820 individuals, as the control group, by age and gender. Incidence of MS in both groups was calculated. Cox proportional-hazards regressions were performed for investigating hazard ratios (HR) for MS between groups.RESULTS:
Septicemia patients had a 3.06-fold (95% CI 2.16-4.32, P < 0.001) greater risk of developing MS than the matched group. In addition, higher severity of septicemia was associated with higher risk of developing MS (moderate HR = 4.03, 95% CI 2.53-6.45, P < 0.001; severe HR = 11.1, 95% CI 7.01-17.7, P < 0.001). Similar results also occurred in both male and female patients with septicemia (male HR = 4.06, 95% CI 2.17-7.58, P < 0.001; female HR = 2.72, 95% CI 1.79-4.11, P < 0.001). Patients without counterpart comorbidities had a significantly higher risk of MS than the controlled group (HR = 3.02, 95% CI 2.10-4.35, P < 0.001).CONCLUSION:
The results indicated septicemia is linked to an increased risk for MS. Aggressively preventing and treating septicemia may be warranted for one of precautionary strategies of MS.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sepse
/
Esclerose Múltipla
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
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Aged
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Female
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Humans
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Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
QJM
Ano de publicação:
2018
Tipo de documento:
Article