Synthesis and biological activities of dithiocarbamates containing 2(5H)-furanone-piperazine.
Eur J Med Chem
; 155: 165-170, 2018 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-29886320
ABSTRACT
A series of new dithiocarbamates containing a 2(5H)-furanone-piperazine group was synthesized. These compounds show good in vitro cytoxic activity. Among them, compound 6c exhibits the best inhibitory activity against HeLa cell lines with an IC50 of 0.06⯱â¯0.01⯵M for 72â¯h, and it has good inhibitory activity against SMMC-7721â¯cell lines with an IC50 of 0.006⯱â¯0.04⯵M for 72â¯h, but the toxicity was lower against LO2 cell lines with an IC50 of 45.76⯱â¯0.01⯵M. The result showed that compound 6c is far more cytoxic towards cancer cell lines than towards benign cell lines compared with cytosine arabinoside (ARA) in vitro.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piperazinas
/
Tiocarbamatos
/
Furanos
Limite:
Humans
Idioma:
En
Revista:
Eur J Med Chem
Ano de publicação:
2018
Tipo de documento:
Article