Synthesis and biological activities of dithiocarbamates containing 2(5H)-furanone-piperazine.

ABSTRACT

A series of new dithiocarbamates containing a 2(5H)-furanone-piperazine group was synthesized. These compounds show good in vitro cytoxic activity. Among them, compound 6c exhibits the best inhibitory activity against HeLa cell lines with an IC50 of 0.06 ±â€¯0.01 µM for 72 h, and it has good inhibitory activity against SMMC-7721 cell lines with an IC50 of 0.006 ±â€¯0.04 µM for 72 h, but the toxicity was lower against LO2 cell lines with an IC50 of 45.76 ±â€¯0.01 µM. The result showed that compound 6c is far more cytoxic towards cancer cell lines than towards benign cell lines compared with cytosine arabinoside (ARA) in vitro.