Tandem repeated irritation test (TRIT) studies and clinical relevance: Post 2006.
Cutan Ocul Toxicol
; 38(4): 309-314, 2019 Dec.
Article
em En
| MEDLINE
| ID: mdl-29886752
Background/Aims: Single or multiple applications of irritants can lead to occupational contact dermatitis, and most commonly irritant contact dermatitis (ICD). Tandem irritation, the sequential application of two irritants to a target skin area, has been studied using the Tandem Repeated Irritation Test (TRIT) to provide a more accurate representation of skin irritation. Objective: Here we present an update to Kartono's review on tandem irritation studies since 2006. Methods: We surveyed the literature available on PubMed, Embase, Google Scholar, and the UCSF Dermatology library databases since 2006. Results and discussion: The studies included discuss the tandem effects of common chemical irritants, organic solvents, occlusion as well as clinical relevance - and enlarge our ability to discern whether multiple chemical exposures are more or less likely to enhance irritation.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Testes de Toxicidade
/
Irritantes
Tipo de estudo:
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Cutan Ocul Toxicol
Ano de publicação:
2019
Tipo de documento:
Article