IL­1ß and TNF­&#945; suppress TGF­ß­promoted NGF expression in periodontal ligament­derived fibroblasts through inactivation of TGF­ß­induced Smad2/3­ and p38 MAPK­mediated signals.

Ohta, Maiko; Chosa, Naoyuki; Kyakumoto, Seiko; Yokota, Seiji; Okubo, Naoto; Nemoto, Akira; Kamo, Masaharu; Joh, Shigeharu; Satoh, Kenichi; Ishisaki, Akira

IL1ß and TNFα suppress TGFßpromoted NGF expression in periodontal ligamentderived fibroblasts through inactivation of TGFßinduced Smad2/3 and p38 MAPKmediated signals.

Ohta, Maiko; Chosa, Naoyuki; Kyakumoto, Seiko; Yokota, Seiji; Okubo, Naoto; Nemoto, Akira; Kamo, Masaharu; Joh, Shigeharu; Satoh, Kenichi; Ishisaki, Akira.

Afiliação

Ohta M; Division of Cellular Biosignal Sciences, Department of Biochemistry, Iwate Medical University, Shiwagun, Iwate 0283694, Japan.
Chosa N; Division of Cellular Biosignal Sciences, Department of Biochemistry, Iwate Medical University, Shiwagun, Iwate 0283694, Japan.
Kyakumoto S; Division of Cellular Biosignal Sciences, Department of Biochemistry, Iwate Medical University, Shiwagun, Iwate 0283694, Japan.
Yokota S; Division of Cellular Biosignal Sciences, Department of Biochemistry, Iwate Medical University, Shiwagun, Iwate 0283694, Japan.
Okubo N; Laboratory of Pathophysiology and Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University, Kitaku, Sapporo 0600812, Japan.
Nemoto A; Division of Operative Dentistry and Endodontics, Department of Conservative Dentistry, Iwate Medical University, Morioka, Iwate 0208505, Japan.
Kamo M; Division of Cellular Biosignal Sciences, Department of Biochemistry, Iwate Medical University, Shiwagun, Iwate 0283694, Japan.
Joh S; Division of Oral and Dysphasia Rehabilitation, Department of Prosthodontics, Iwate Medical University, Morioka, Iwate 0208505, Japan.
Satoh K; Division of Dental Anesthesia, Department of Reconstructive Oral and Maxillofacial Surgery, Iwate Medical University, Morioka, Iwate 0208505, Japan.
Ishisaki A; Division of Cellular Biosignal Sciences, Department of Biochemistry, Iwate Medical University, Shiwagun, Iwate 0283694, Japan.

Int J Mol Med ; 42(3): 1484-1494, 2018 Sep.

Article em En | MEDLINE | ID: mdl-29901090

Assuntos

Fibroblastos/metabolismo; Interleucina-1beta/farmacologia; Fator de Crescimento Neural/metabolismo; Ligamento Periodontal/citologia; Proteínas Smad/metabolismo; Fator de Crescimento Transformador beta/farmacologia; Fator de Necrose Tumoral alfa/farmacologia; Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo; Trifosfato de Adenosina/análogos & derivados; Trifosfato de Adenosina/farmacologia; Animais; Fibroblastos/efeitos dos fármacos; Humanos; Fator de Crescimento Neural/genética; Neuritos/efeitos dos fármacos; Neuritos/metabolismo; Células PC12; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Ratos; Receptores de Fatores de Crescimento Transformadores beta/metabolismo; Transdução de Sinais/efeitos dos fármacos; Tirosina 3-Mono-Oxigenase/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ligamento Periodontal / Fator de Crescimento Transformador beta / Fator de Necrose Tumoral alfa / Fator de Crescimento Neural / Proteínas Quinases p38 Ativadas por Mitógeno / Proteínas Smad / Interleucina-1beta / Fibroblastos Limite: Animals / Humans Idioma: En Revista: Int J Mol Med Ano de publicação: 2018 Tipo de documento: Article

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