Hyperferritinemia: causes and significance in a general hospital.
Hematology
; 23(10): 817-822, 2018 Dec.
Article
em En
| MEDLINE
| ID: mdl-29914346
ABSTRACT
OBJECTIVE:
To elucidate conditions which cause elevation of the serum ferritin, extent of the elevation in each condition, and clinical relevance of hyperferritinemia in general practice.METHODS:
We retrospectively studied medical records of all patients who had at least one serum ferritin measurement above 500â µgâ L-1. Patients who had a marked elevation of the serum ferritin over 10,000â µgâ L-1 were studied separately.RESULTS:
We studied 1394 patients to identify the etiologies of hyperferritinemia. Median serum ferritin level was 1024â µgâ L-1 and 49.2% had ferritin levels of 501-1000â µgâ L-1. The most frequent cause of hyperferritinemia was non-human immunodeficiency virus infection followed by solid tumor, liver dysfunction, renal failure, and hematological malignancy. The distributions of the causes were different among groups stratified by the ferritin level. Forty-one percent had multiple causes and there was a tendency that the more underlying causes a patient had, the higher the ferritin level. Each condition led to a wide range of the ferritin level, and some patients could present with marked hyperferritinemia. Seventy percent of 111 patients with marked hyperferritinemia had multiple etiologies and a variety of diseases could lead to marked hyperferritinemia by themselves.DISCUSSION:
Patients with hyperferritinemia frequently had multiple conditions. The level of the serum ferritin was determined by the underlying conditions to a certain extent; however, the variation was significant. While patients with marked hyperferritinemia mostly had multiple underlying causes, various diseases could cause hyperferritinemia by themselves.CONCLUSION:
Hyperferritinemia is associated with both etiology and the number of underlying causes.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ferritinas
/
Transtornos Hemorrágicos
Tipo de estudo:
Etiology_studies
/
Observational_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Hematology
Ano de publicação:
2018
Tipo de documento:
Article