Upregulation of UDP-Glucuronosyltransferases 1a1 and 1a7 Are Involved in Altered Puerarin Pharmacokinetics in Type II Diabetic Rats.

Dong, Songtao; Zhang, Maofan; Niu, Huimin; Jiang, Kunyu; Jiang, Jialei; Ma, Yinglin; Wang, Xin; Meng, Shengnan

Dong, Songtao; Zhang, Maofan; Niu, Huimin; Jiang, Kunyu; Jiang, Jialei; Ma, Yinglin; Wang, Xin; Meng, Shengnan.

Afiliação

Dong S; Department of Pharmaceutics, School of Pharmacy, China Medical University, Shenyang 110122, China. dongsongtao8886@163.com.
Zhang M; Department of Pharmaceutics, School of Pharmacy, China Medical University, Shenyang 110122, China. mfzhang@cmu.edu.cn.
Niu H; Department of Pharmaceutics, School of Pharmacy, China Medical University, Shenyang 110122, China. 15804066249@163.com.
Jiang K; Department of Pharmaceutics, School of Pharmacy, China Medical University, Shenyang 110122, China. jiangkunyu87@163.com.
Jiang J; Department of Pharmaceutics, School of Pharmacy, China Medical University, Shenyang 110122, China. 15804002893@163.com.
Ma Y; Department of Pharmaceutics, School of Pharmacy, China Medical University, Shenyang 110122, China. ylmacmu@163.com.
Wang X; Department of Pharmaceutics, School of Pharmacy, China Medical University, Shenyang 110122, China. WangXinCMU@126.com.
Meng S; Department of Pharmaceutics, School of Pharmacy, China Medical University, Shenyang 110122, China. shnmeng@hotmail.com.

Molecules ; 23(6)2018 Jun 20.

Article em En | MEDLINE | ID: mdl-29925761

Assuntos

Diabetes Mellitus Experimental/metabolismo; Glucuronosiltransferase/metabolismo; Hipoglicemiantes/farmacocinética; Isoflavonas/farmacocinética; Extratos Vegetais/farmacocinética; Administração Intravenosa; Administração Oral; Animais; Descoberta de Drogas; Humanos; Hipoglicemiantes/administração & dosagem; Hipoglicemiantes/química; Isoflavonas/administração & dosagem; Isoflavonas/química; Masculino; Microssomos Hepáticos/metabolismo; Extratos Vegetais/química; Raízes de Plantas/química; Ratos; Ratos Sprague-Dawley; Traqueófitas/química; Regulação para Cima; Difosfato de Uridina/metabolismo

Palavras-chave

Ugt1a1; Ugt1a7; diabetes; pharmacokinetics; puerarin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Glucuronosiltransferase / Diabetes Mellitus Experimental / Hipoglicemiantes / Isoflavonas Limite: Animals / Humans / Male Idioma: En Revista: Molecules Ano de publicação: 2018 Tipo de documento: Article

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