Chemical Synthesis of Gangliosides.
Methods Mol Biol
; 1804: 293-310, 2018.
Article
em En
| MEDLINE
| ID: mdl-29926415
ABSTRACT
Various methods for the chemical synthesis of gangliosides have been investigated to date and numerous natural gangliosides and their structural analogues have been synthesized during the past three decades. Key technologies in the synthesis of gangliosides include α-selective sialylation and introduction of the ceramide moiety into the oligosaccharide chain. This chapter introduces two major strategies for ganglioside synthesis-the most commonly used strategy and the recently developed glucosylceramide cassette approach. Synthetic procedures for selected reactions are also presented.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Química Orgânica
/
Gangliosídeos
Limite:
Animals
Idioma:
En
Revista:
Methods Mol Biol
Ano de publicação:
2018
Tipo de documento:
Article