Altered synaptic and firing properties of cerebellar Purkinje cells in a mouse model of ARSACS.

Ady, Visou; Toscano-Márquez, Brenda; Nath, Moushumi; Chang, Philip K; Hui, Jeanette; Cook, Anna; Charron, François; Larivière, Roxanne; Brais, Bernard; McKinney, R Anne; Watt, Alanna J

Ady, Visou; Toscano-Márquez, Brenda; Nath, Moushumi; Chang, Philip K; Hui, Jeanette; Cook, Anna; Charron, François; Larivière, Roxanne; Brais, Bernard; McKinney, R Anne; Watt, Alanna J.

Afiliação

Ady V; Department of Biology, McGill University, Montréal, Canada.
Toscano-Márquez B; Department of Biology, McGill University, Montréal, Canada.
Nath M; Department of Biology, McGill University, Montréal, Canada.
Chang PK; Department of Pharmacology and Therapeutics, McGill University, Montréal, Canada.
Hui J; Department of Biology, McGill University, Montréal, Canada.
Cook A; Department of Biology, McGill University, Montréal, Canada.
Charron F; Department of Pharmacology and Therapeutics, McGill University, Montréal, Canada.
Larivière R; Department of Neurology and Neurosurgery, Montréal Neurological Institute, McGill University, Montréal, Canada.
Brais B; Department of Neurology and Neurosurgery, Montréal Neurological Institute, McGill University, Montréal, Canada.
McKinney RA; Department of Pharmacology and Therapeutics, McGill University, Montréal, Canada.
Watt AJ; Department of Biology, McGill University, Montréal, Canada.

J Physiol ; 596(17): 4253-4267, 2018 09.

Article em En | MEDLINE | ID: mdl-29928778

Assuntos

Ataxia Cerebelar/fisiopatologia; Modelos Animais de Doenças; Proteínas de Choque Térmico/fisiologia; Espasticidade Muscular/fisiopatologia; Células de Purkinje/fisiologia; Ataxias Espinocerebelares/congênito; Sinapses/fisiologia; Animais; Comportamento Animal; Humanos; Camundongos; Camundongos Knockout; Mutação; Células de Purkinje/citologia; Ataxias Espinocerebelares/fisiopatologia

Palavras-chave

action potential; cerebellum; deep cerebellar nuclei; synaptic currents

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Células de Purkinje / Sinapses / Ataxia Cerebelar / Ataxias Espinocerebelares / Modelos Animais de Doenças / Proteínas de Choque Térmico / Espasticidade Muscular Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Physiol Ano de publicação: 2018 Tipo de documento: Article

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