High prevalence of house dust mite sensitization in children with severe asthma living at high altitude in a tropical country.
Pediatr Pulmonol
; 53(10): 1356-1361, 2018 10.
Article
em En
| MEDLINE
| ID: mdl-29938928
ABSTRACT
BACKGROUND:
Some studies, mainly in Europe, have shown a low level of sensitization to house dust mite (HDM) allergens at high altitude (HA). Differently, some others in tropical countries have shown a higher level. The aim of this study was to evaluate allergens sensitization, including HDM, in children with severe asthma (SA), residents at HA in a tropical middle-income developing country.METHODS:
Observational, analytical, cross-sectional study in children aged 6-15 years old with SA at HA (2640 m). Skin prick tests (SPT), serum IgE, exhaled fraction of nitric oxide (FENO ), spirometry, and asthma questionnaire (ACT) were performed. Associations were explored by Pearson or Spearman coefficients.RESULTS:
We included 61 children. Most patients were male (61.3%), median age 10 years (Interquartile range [IQR] 8-12), median BMI 17 kg/m2 (IQR 16-20); Median of positive SPT 2 (IQR 2-3). At least one SPT was positive in 88.7% of patients and 87.9% were positive for at least one HDM. Serum IgE 348 UI/mL (IQR 154-760) and FENO 22 ppb (IQR 9-41). Prebronchodilator values were (% predicted) FVC 109.7% (±15.5%), FEV1 98.4% (±16.3); FEV1 /FVC 82% (±8%). SPT were inversely correlated with the FEV1 /FVC (Rho -0.34; 95% CI -0.55 a -0.09; P = 0.008).CONCLUSIONS:
These children with SA living at HA in a tropical middle-income developing country have a high prevalence of HDM sensitization. One explanation for this might be that tropical conditions, such as temperature and humidity, could modify the effect of the altitude on asthma.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Asma
/
Clima Tropical
/
Pyroglyphidae
/
Antígenos de Dermatophagoides
/
Altitude
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Animals
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Child
/
Female
/
Humans
/
Male
País/Região como assunto:
America do sul
/
Colombia
Idioma:
En
Revista:
Pediatr Pulmonol
Ano de publicação:
2018
Tipo de documento:
Article