Application of FT-NIR Analysis for In-line and Real-Time Monitoring of Pharmaceutical Hot Melt Extrusion: a Technical Note.
AAPS PharmSciTech
; 19(8): 3425-3429, 2018 Nov.
Article
em En
| MEDLINE
| ID: mdl-29948985
Continuous manufacturing, a gaining interest paradigm in the pharmaceutical industry, requires in-process monitoring of critical process parameters to ensure product consistency. This study demonstrated the application of Fourier transform near-infrared (FT-NIR) spectroscopy in conjunction with chemometrics modeling for in-line hot melt extrusion process monitoring. The obtained results suggested that inline FT-NIR analysis, along with a tailored NIR reflector, is a viable process analytical tool to monitor active pharmaceutical ingredient concentration as well as processing parameters.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistemas Computacionais
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Tecnologia Farmacêutica
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Análise de Fourier
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Temperatura Alta
Idioma:
En
Revista:
AAPS PharmSciTech
Ano de publicação:
2018
Tipo de documento:
Article