Lipid Peroxidation, Advanced Glycation end Products and Antioxidant Status in Patients on Dialysis.

ABSTRACT

Oxidative stress increases the risk of cardiovascular disease in patients on chronic dialysis. In this study, we examined markers of oxidative stress and antioxidant status in haemodialysis (HD) patients in order to find out their relationship to the dialysis treatment. Study included 25 patients on long-term haemodialysis (HD) and 30 control subjects. Levels of malonyldialdehyde+4-hydroxyalkenes (MDA+4-HNE), advanced glycation end products (AGEs) and superoxide dismutase (Cu/ZnSOD) were assayed in plasma or serum. Mean plasma level of MDA+4-HNE was 2-fold higher and AGEs 4-fold higher in HD patients, comparing to control subjects. Also Cu/ZnSOD were significantly elevated in dialysis patients. Positive correlation between AGEs as well as Cu/ZnSOD concentration and duration of HD treatment (r=0,68, p<0,007; r=0,53, p<0,006) was found. Significantly increased oxidative stress may accelerate atherosclerotic changes and cardiovascular complications in haemodialysis patients but seems to be, at least in part, counteracted by enhanced antioxidant capacity.