A speed-fidelity trade-off determines the mutation rate and virulence of an RNA virus.

Fitzsimmons, William J; Woods, Robert J; McCrone, John T; Woodman, Andrew; Arnold, Jamie J; Yennawar, Madhumita; Evans, Richard; Cameron, Craig E; Lauring, Adam S

Fitzsimmons, William J; Woods, Robert J; McCrone, John T; Woodman, Andrew; Arnold, Jamie J; Yennawar, Madhumita; Evans, Richard; Cameron, Craig E; Lauring, Adam S.

Afiliação

Fitzsimmons WJ; Division of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America.
Woods RJ; Division of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America.
McCrone JT; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, United States of America.
Woodman A; Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America.
Arnold JJ; Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America.
Yennawar M; Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America.
Evans R; Department of Epidemiology, University of Michigan, Ann Arbor, Michigan United States of America.
Cameron CE; Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America.
Lauring AS; Division of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America.

PLoS Biol ; 16(6): e2006459, 2018 06.

Article em En | MEDLINE | ID: mdl-29953453

Assuntos

Taxa de Mutação; Vírus de RNA/genética; Vírus de RNA/patogenicidade; Virulência/genética; Células 3T3; Substituição de Aminoácidos; Animais; Evolução Molecular Direcionada; Feminino; Interações entre Hospedeiro e Microrganismos/genética; Cinética; Masculino; Camundongos; Camundongos Transgênicos; Modelos Genéticos; Mutagênese Sítio-Dirigida; Polimorfismo de Nucleotídeo Único; Vírus de RNA/fisiologia; RNA Polimerase Dependente de RNA/genética; RNA Polimerase Dependente de RNA/metabolismo; Theilovirus/genética; Theilovirus/patogenicidade; Theilovirus/fisiologia; Proteínas Virais/genética; Proteínas Virais/metabolismo; Replicação Viral/genética

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus de RNA / Virulência / Taxa de Mutação Limite: Animals Idioma: En Revista: PLoS Biol Ano de publicação: 2018 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google