Long-term outcomes of patients with intraductal growth sub-type of intrahepatic cholangiocarcinoma.
HPB (Oxford)
; 20(12): 1189-1197, 2018 12.
Article
em En
| MEDLINE
| ID: mdl-29958811
ABSTRACT
BACKGROUND:
Intraductal-growth (IG) type of intrahepatic cholangiocarcinoma (ICC) may be associated with a favorable prognosis compared with mass-forming (MF) and periductal-infiltrating (PI) ICC.METHODS:
The clinico-pathological characteristics and long-term outcomes of 1206 patients undergoing liver resection for ICC were compared based on the ICC morphological classification.RESULTS:
Compared with MF patients, IG patients had a higher incidence of poor/un-differentiated tumor, lympho-vascular, and perineural invasion (poor/un-differentiated MF, 18% vs. IG, 24%; lympho-vascular invasion MF, 30% vs. IG, 35%; perineural invasion MF, 17% vs. IG, 33%; all p > 0.05). The pattern of recurrence was different among MF patients (intrahepatic only 63%; extrahepatic only 22%; both intra- and extrahepatic 16%) versus IG patients (intrahepatic only 46%; extrahepatic 25%; both intra- and extrahepatic 29%) (p < 0.001). Moreover, while 78% of patients with MF had an early recurrence (<18 months from surgery), 59% of IG patients had and early recurrence (p = 0.039). On multivariable analysis, after controlling for competing risk factors, IG patients had a similar prognosis as MF patients (HR 0.90, p = 0.69).CONCLUSION:
While IG patients more frequently presented with more adverse pathological characteristics, the prognosis of IG patients was comparable with MF patients after controlling for all these adverse factors.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias dos Ductos Biliares
/
Colangiocarcinoma
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Proliferação de Células
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
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Male
/
Middle aged
País/Região como assunto:
America do norte
/
Asia
/
Europa
/
Oceania
Idioma:
En
Revista:
HPB (Oxford)
Ano de publicação:
2018
Tipo de documento:
Article