Wnt-7a Stimulates Dendritic Spine Morphogenesis and PSD-95 Expression Through Canonical Signaling.
Mol Neurobiol
; 56(3): 1870-1882, 2019 Mar.
Article
em En
| MEDLINE
| ID: mdl-29967987
ABSTRACT
Wnt signaling regulates brain development and synapse maturation; however, the precise molecular mechanism remains elusive. Here, we report that Wnt-7a stimulates dendritic spine morphogenesis in the hippocampus via glycogen synthase kinase-3 ß (GSK-3ß) inhibition, triggering ß-catenin/T cell factor/lymphoid enhancer factor (TCF/LEF)-dependent gene transcription and promoting postsynaptic density-95 (PSD-95) protein expression. In addition, wild-type mice treated with an inhibitor of ß-catenin/TCF/LEF-mediated transcription showed a reduction in spatial memory acquisition accompanied by a reduction in PSD-95 and decreases in spine density measured by Golgi staining, suggesting that PSD-95 is a novel Wnt target gene. Together, our data strongly demonstrate that Wnt-dependent target gene transcription is essential to hippocampal synaptic plasticity.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
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Espinhas Dendríticas
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Proteínas Wnt
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Proteína 4 Homóloga a Disks-Large
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Plasticidade Neuronal
Limite:
Animals
Idioma:
En
Revista:
Mol Neurobiol
Ano de publicação:
2019
Tipo de documento:
Article