CYP3A4*22 Impairs the Elimination of Ticagrelor, But Has No Significant Effect on the Bioactivation of Clopidogrel or Prasugrel.

Holmberg, Mikko T; Tornio, Aleksi; Paile-Hyvärinen, Maria; Tarkiainen, E Katriina; Neuvonen, Mikko; Neuvonen, Pertti J; Backman, Janne T; Niemi, Mikko

Holmberg, Mikko T; Tornio, Aleksi; Paile-Hyvärinen, Maria; Tarkiainen, E Katriina; Neuvonen, Mikko; Neuvonen, Pertti J; Backman, Janne T; Niemi, Mikko.

Afiliação

Holmberg MT; Department of Clinical Pharmacology, University of Helsinki and HUSLAB, Helsinki University Central Hospital, Helsinki, Finland.
Tornio A; Department of Clinical Pharmacology, University of Helsinki and HUSLAB, Helsinki University Central Hospital, Helsinki, Finland.
Paile-Hyvärinen M; Department of Clinical Pharmacology, University of Helsinki and HUSLAB, Helsinki University Central Hospital, Helsinki, Finland.
Tarkiainen EK; Department of Clinical Pharmacology, University of Helsinki and HUSLAB, Helsinki University Central Hospital, Helsinki, Finland.
Neuvonen M; Department of Clinical Pharmacology, University of Helsinki and HUSLAB, Helsinki University Central Hospital, Helsinki, Finland.
Neuvonen PJ; Department of Clinical Pharmacology, University of Helsinki and HUSLAB, Helsinki University Central Hospital, Helsinki, Finland.
Backman JT; Department of Clinical Pharmacology, University of Helsinki and HUSLAB, Helsinki University Central Hospital, Helsinki, Finland.
Niemi M; Department of Clinical Pharmacology, University of Helsinki and HUSLAB, Helsinki University Central Hospital, Helsinki, Finland.

Clin Pharmacol Ther ; 105(2): 448-457, 2019 02.

Article em En | MEDLINE | ID: mdl-29998574

Assuntos

Clopidogrel/farmacocinética; Citocromo P-450 CYP3A/metabolismo; Inibidores da Agregação Plaquetária/farmacocinética; Cloridrato de Prasugrel/farmacocinética; Ticagrelor/farmacocinética; Ativação Metabólica/genética; Adulto; Área Sob a Curva; Clopidogrel/farmacologia; Feminino; Variação Genética; Genótipo; Voluntários Saudáveis; Humanos; Masculino; Agregação Plaquetária/efeitos dos fármacos; Inibidores da Agregação Plaquetária/farmacologia; Testes de Função Plaquetária; Cloridrato de Prasugrel/farmacologia; Ticagrelor/farmacologia; Adulto Jovem

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores da Agregação Plaquetária / Citocromo P-450 CYP3A / Cloridrato de Prasugrel / Clopidogrel / Ticagrelor Tipo de estudo: Prognostic_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Clin Pharmacol Ther Ano de publicação: 2019 Tipo de documento: Article

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