Increased Expression of Thioredoxin-1 Binding Protein-2 in Placentas in Preeclampsia.
J Reprod Med
; 62(1-2): 21-5, 2017.
Article
em En
| MEDLINE
| ID: mdl-29999276
ABSTRACT
OBJECTIVE:
To examine the expressions of thioredoxin-1 (TRX-1) and thioredoxin-1 binding protein-2 (TBP-2) in placentas affected by preeclampsia. STUDYDESIGN:
We examined the mRNA levels of TRX-1, TBP-2, cyclooxygenase-2 (COX-2), and tumor necrosis factor-α (TNF-α) in preeclamptic (n=20) and normal placentas (n=18) by quantitative reverse transcriptase-polymerase chain reaction.RESULTS:
We found the mRNA level of TRX-1 was significantly decreased (p<0.005), while the mRNA levels of TBP-2, COX-2, and TNF-α were significantly increased in the placentas in preeclampsia when compared to the normal group (p<0.005).CONCLUSION:
These data suggest that TBP-2 may play roles in the pathophysiology of preeclampsia, probably by contributing to oxidative stress and inflammation. Thus, TBP-2 may be a potential therapeutic target for preeclampsia.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Placenta
/
Pré-Eclâmpsia
/
Tiorredoxinas
/
Proteínas de Transporte
Tipo de estudo:
Observational_studies
Limite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
J Reprod Med
Ano de publicação:
2017
Tipo de documento:
Article