S100A10, a novel biomarker in pancreatic ductal adenocarcinoma.
Mol Oncol
; 12(11): 1895-1916, 2018 11.
Article
em En
| MEDLINE
| ID: mdl-30009399
ABSTRACT
Pancreatic cancer is arguably the deadliest cancer type. The efficacy of current therapies is often hindered by the inability to predict patient outcome. As such, the development of tools for early detection and risk prediction is key for improving outcome and quality of life. Here, we introduce the plasminogen receptor S100A10 as a novel predictive biomarker and a driver of pancreatic tumor growth and invasion. We demonstrated that S100A10 mRNA and protein are overexpressed in human pancreatic tumors compared to normal ducts and nonductal stroma. S100A10 mRNA and methylation status were predictive of overall survival and recurrence-free survival across multiple patient cohorts. S100A10 expression was driven by promoter methylation and the oncogene KRAS. S100A10 knockdown reduced surface plasminogen activation, invasiveness, and in vivo growth of pancreatic cancer cell lines. These findings delineate the clinical and functional contribution of S100A10 as a biomarker in pancreatic cancer.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
6_ODS3_enfermedades_notrasmisibles
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
/
Proteínas S100
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Biomarcadores Tumorais
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Anexina A2
/
Carcinoma Ductal Pancreático
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Proteínas de Neoplasias
Tipo de estudo:
Prognostic_studies
/
Screening_studies
Aspecto:
Patient_preference
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Mol Oncol
Ano de publicação:
2018
Tipo de documento:
Article