bFGF expression is differentially regulated by cocaine seeking versus extinction in learning-related brain regions.
Learn Mem
; 25(8): 361-368, 2018 08.
Article
em En
| MEDLINE
| ID: mdl-30012881
ABSTRACT
In cocaine use disorder, relapse can be elicited by drug-associated cues despite long periods of abstinence. The persistence of drug-associated cues in eliciting drug seeking suggests enduring changes in structural and functional plasticity, which may be mediated by basic fibroblast growth factor (bFGF, FGF2). Stimulant drug use increases bFGF expression in reward- and learning-related brain regions, such as the infralimbic medial-prefrontal cortex (IL-mPFC), and we previously found that this increase was reversed by extinction. However, whether bFGF expression is similarly modified in other brain regions is unknown. Therefore, we used the conditioned place preference (CPP) paradigm to assess bFGF expression following cocaine-associated CPP or extinction of that CPP within the mPFC, nucleus accumbens (NAc), hippocampus (Hipp), and basolateral amygdala (BLA). bFGF expression was increased in IL-mPFC and NAc-Core and -Shell following a cocaine-associated CPP, an effect reversed by extinction. Conversely, bFGF expression was increased in BLA following extinction, but no significant changes were observed in PL-mPFC or either dorsal or ventral Hipp. These results demonstrate differential regulation of bFGF following cocaine-associated CPP or extinction of that CPP in discrete brain regions. Changes in bFGF expression may regulate long-lasting drug-induced plasticity that underlies persistent drug-associated memories, and therefore present potential prophylactic targets.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Comportamento Animal
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Fator 2 de Crescimento de Fibroblastos
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Córtex Pré-Frontal
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Cocaína
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Inibidores da Captação de Dopamina
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Condicionamento Clássico
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Extinção Psicológica
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Complexo Nuclear Basolateral da Amígdala
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Hipocampo
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Núcleo Accumbens
Limite:
Animals
Idioma:
En
Revista:
Learn Mem
Ano de publicação:
2018
Tipo de documento:
Article