Discovery, Synthesis, Pharmacological Profiling, and Biological Characterization of Brintonamides A-E, Novel Dual Protease and GPCR Modulators from a Marine Cyanobacterium.

Al-Awadhi, Fatma H; Gao, Bowen; Rezaei, Mohammad A; Kwan, Jason C; Li, Chenglong; Ye, Tao; Paul, Valerie J; Luesch, Hendrik

Al-Awadhi, Fatma H; Gao, Bowen; Rezaei, Mohammad A; Kwan, Jason C; Li, Chenglong; Ye, Tao; Paul, Valerie J; Luesch, Hendrik.

Afiliação

Al-Awadhi FH; Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3) , University of Florida , 1345 Center Drive , Gainesville , Florida 32610 , United States.
Gao B; Department of Pharmaceutical Chemistry, Faculty of Pharmacy , Kuwait University , P.O. Box 24923, Safat 13110 , Kuwait.
Rezaei MA; State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology , Peking University Shenzhen Graduate School , Xili, Nanshan District , Shenzhen , 518055 , China.
Kwan JC; Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3) , University of Florida , 1345 Center Drive , Gainesville , Florida 32610 , United States.
Li C; Department of Chemistry , University of Florida , Gainesville , Florida 32611 , United States.
Ye T; Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3) , University of Florida , 1345 Center Drive , Gainesville , Florida 32610 , United States.
Paul VJ; Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3) , University of Florida , 1345 Center Drive , Gainesville , Florida 32610 , United States.
Luesch H; State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology , Peking University Shenzhen Graduate School , Xili, Nanshan District , Shenzhen , 518055 , China.

J Med Chem ; 61(14): 6364-6378, 2018 Jul 26.

Article em En | MEDLINE | ID: mdl-30015488

Assuntos

Amidas/síntese química; Amidas/farmacologia; Cianobactérias/química; Desenho de Fármacos; Calicreínas/antagonistas & inibidores; Receptores Acoplados a Proteínas G/metabolismo; Amidas/química; Linhagem Celular Tumoral; Movimento Celular/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Técnicas de Química Sintética; Humanos; Concentração Inibidora 50; Modelos Moleculares; Inibidores de Proteases/síntese química; Inibidores de Proteases/química; Inibidores de Proteases/farmacologia; Conformação Proteica; Receptores Acoplados a Proteínas G/química

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Calicreínas / Desenho de Fármacos / Cianobactérias / Receptores Acoplados a Proteínas G / Amidas Limite: Humans Idioma: En Revista: J Med Chem Ano de publicação: 2018 Tipo de documento: Article

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