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Crystal structure of an L chain optimised 14F7 anti-ganglioside Fv suggests a unique tumour-specificity through an unusual H-chain CDR3 architecture.
Bjerregaard-Andersen, Kaare; Johannesen, Hedda; Abdel-Rahman, Noha; Heggelund, Julie Elisabeth; Hoås, Helene Mykland; Abraha, Fana; Bousquet, Paula A; Høydahl, Lene Støkken; Burschowsky, Daniel; Rojas, Gertrudis; Oscarson, Stefan; Løset, Geir Åge; Krengel, Ute.
Afiliação
  • Bjerregaard-Andersen K; Department of Chemistry, University of Oslo, NO-0315 Oslo, Norway. kaarebj@kjemi.uio.no.
  • Johannesen H; Department of Chemistry, University of Oslo, NO-0315 Oslo, Norway.
  • Abdel-Rahman N; Department of Chemistry, University of Oslo, NO-0315 Oslo, Norway.
  • Heggelund JE; Department of Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.
  • Hoås HM; Department of Chemistry, University of Oslo, NO-0315 Oslo, Norway.
  • Abraha F; School of Biomedical Sciences, University of Leeds, Leeds, LS2 9JT, UK.
  • Bousquet PA; Department of Chemistry, University of Oslo, NO-0315 Oslo, Norway.
  • Høydahl LS; School of Chemistry, University College Dublin, Belfield, Dublin, 4, Ireland.
  • Burschowsky D; Department of Chemistry, University of Oslo, NO-0315 Oslo, Norway.
  • Rojas G; Centre for Immune Regulation and Department of Immunology, University of Oslo and Oslo University Hospital, NO-0372 Oslo, Norway.
  • Oscarson S; Department of Chemistry, University of Oslo, NO-0315 Oslo, Norway.
  • Løset GÅ; Leicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, LE1 7HB, UK.
  • Krengel U; Center of Molecular Immunology, Calle 216 esq 15, Atabey, Playa, La Habana, CP, 11300, Cuba.
Sci Rep ; 8(1): 10836, 2018 Jul 18.
Article em En | MEDLINE | ID: mdl-30022069
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Região Variável de Imunoglobulina / Cadeias Pesadas de Imunoglobulinas / Cadeias Leves de Imunoglobulina / Anticorpos de Cadeia Única / Gangliosídeo G(M3) / Anticorpos Monoclonais / Neoplasias Tipo de estudo: Guideline Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2018 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Região Variável de Imunoglobulina / Cadeias Pesadas de Imunoglobulinas / Cadeias Leves de Imunoglobulina / Anticorpos de Cadeia Única / Gangliosídeo G(M3) / Anticorpos Monoclonais / Neoplasias Tipo de estudo: Guideline Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2018 Tipo de documento: Article