p53 upregulated by HIF-1&#945; promotes hypoxia-induced G2/M arrest and renal fibrosis in vitro and in vivo.

Liu, Limin; Zhang, Peng; Bai, Ming; He, Lijie; Zhang, Lei; Liu, Ting; Yang, Zhen; Duan, Menglu; Liu, Minna; Liu, Baojian; Du, Rui; Qian, Qi; Sun, Shiren

p53 upregulated by HIF-1α promotes hypoxia-induced G2/M arrest and renal fibrosis in vitro and in vivo.

Liu, Limin; Zhang, Peng; Bai, Ming; He, Lijie; Zhang, Lei; Liu, Ting; Yang, Zhen; Duan, Menglu; Liu, Minna; Liu, Baojian; Du, Rui; Qian, Qi; Sun, Shiren.

Afiliação

Liu L; Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Zhang P; State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi'an, China.
Bai M; Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
He L; Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Zhang L; Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Liu T; Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Yang Z; State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi'an, China.
Duan M; Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Liu M; State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi'an, China.
Liu B; Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Du R; State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi'an, China.
Qian Q; Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Sun S; State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi'an, China.

J Mol Cell Biol ; 11(5): 371-382, 2019 05 01.

Article em En | MEDLINE | ID: mdl-30032308

Assuntos

Hipóxia Celular; Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo; Proteína Supressora de Tumor p53/metabolismo; Animais; Sítios de Ligação; Linhagem Celular; Modelos Animais de Doenças; Feminino; Pontos de Checagem da Fase G2 do Ciclo Celular; Humanos; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Interferência de RNA; RNA Interferente Pequeno/metabolismo; Ratos; Ativação Transcricional; Fator de Crescimento Transformador beta/metabolismo; Proteína Supressora de Tumor p53/antagonistas & inibidores; Proteína Supressora de Tumor p53/genética; Regulação para Cima; Obstrução Ureteral/metabolismo; Obstrução Ureteral/patologia

Palavras-chave

HIF-1α; TGF-ß; cell cycle (G2/M) arrest; hypoxia; p53; renal tubulointerstitial fibrosis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hipóxia Celular / Proteína Supressora de Tumor p53 / Subunidade alfa do Fator 1 Induzível por Hipóxia Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: J Mol Cell Biol Ano de publicação: 2019 Tipo de documento: Article

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