Stereoselective bioactivity, acute toxicity and dissipation in typical paddy soils of the chiral fungicide propiconazole.
J Hazard Mater
; 359: 194-202, 2018 10 05.
Article
em En
| MEDLINE
| ID: mdl-30036749
ABSTRACT
Propiconazole is a widely used systemic agricultural triazole fungicide with two chiral centers. In the present study, systemic assessments of propiconazole stereoisomers are reported for the first time, including absolute configuration, stereoselective bioactivity toward pathogens (Ustilaginoidea virens, Magnaporthe oryzae, Fusarium moniliforme, Thanatephorus cucumeris, and Rhizoctonia solani), and stereoselective acute toxicity toward aquatic organisms (Scenedesmus obliquus, and Daphnia magna). Moreover, the stereoselective dissipation of propiconazole in three types of paddy soil under laboratory-controlled conditions (aerobic, anaerobic and sterile) was investigated. The degree of bioactivity and acute toxicity of the propiconazole stereoisomers differed depending on the type of target pathogens and non-target organisms. There were 2.43-23.47 and 1.48-2.13 fold differences between the best and worst stereoisomer in bioactivity and toxicity, respectively. Under aerobic conditions, (2S,4S)-propiconazole and (2S,4R)-propiconazole were preferentially degraded in the three types of soils. However, no significant stereoselectivity was observed under anaerobic and sterile conditions. Propiconazole was configurationally stable throughout the study. In comprehensive consideration of bioactivity, toxicity and environmental behavior, using stereoisomer mixture rather than pure stereoisomer may help to control more species of disease in practical application, and the stereoselectivity should be taken into consideration in risk assessment.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poluentes do Solo
/
Triazóis
/
Fungicidas Industriais
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
J Hazard Mater
Ano de publicação:
2018
Tipo de documento:
Article