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Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
Lee, James J; Wedow, Robbee; Okbay, Aysu; Kong, Edward; Maghzian, Omeed; Zacher, Meghan; Nguyen-Viet, Tuan Anh; Bowers, Peter; Sidorenko, Julia; Karlsson Linnér, Richard; Fontana, Mark Alan; Kundu, Tushar; Lee, Chanwook; Li, Hui; Li, Ruoxi; Royer, Rebecca; Timshel, Pascal N; Walters, Raymond K; Willoughby, Emily A; Yengo, Loïc; Alver, Maris; Bao, Yanchun; Clark, David W; Day, Felix R; Furlotte, Nicholas A; Joshi, Peter K; Kemper, Kathryn E; Kleinman, Aaron; Langenberg, Claudia; Mägi, Reedik; Trampush, Joey W; Verma, Shefali Setia; Wu, Yang; Lam, Max; Zhao, Jing Hua; Zheng, Zhili; Boardman, Jason D; Campbell, Harry; Freese, Jeremy; Harris, Kathleen Mullan; Hayward, Caroline; Herd, Pamela; Kumari, Meena; Lencz, Todd; Luan, Jian'an; Malhotra, Anil K; Metspalu, Andres; Milani, Lili; Ong, Ken K; Perry, John R B.
Afiliação
  • Lee JJ; Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, USA.
  • Wedow R; Department of Sociology, University of Colorado Boulder, Boulder, CO, USA.
  • Okbay A; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.
  • Kong E; Institute of Behavioral Science, University of Colorado Boulder, Boulder, CO, USA.
  • Maghzian O; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. a.okbay@vu.nl.
  • Zacher M; Department of Economics, School of Business and Economics, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. a.okbay@vu.nl.
  • Nguyen-Viet TA; Department of Economics, Harvard University, Cambridge, MA, USA.
  • Bowers P; Department of Economics, Harvard University, Cambridge, MA, USA.
  • Sidorenko J; Department of Sociology, Harvard University, Cambridge, MA, USA.
  • Karlsson Linnér R; Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA.
  • Fontana MA; Department of Economics, Harvard University, Cambridge, MA, USA.
  • Kundu T; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
  • Lee C; Estonian Genome Center, University of Tartu, Tartu, Estonia.
  • Li H; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  • Li R; Department of Economics, School of Business and Economics, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  • Royer R; Institute for Behavior and Biology, Erasmus University Rotterdam, Rotterdam, The Netherlands.
  • Timshel PN; Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA.
  • Walters RK; Center for the Advancement of Value in Musculoskeletal Care, Hospital for Special Surgery, New York, NY, USA.
  • Willoughby EA; Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA.
  • Yengo L; Department of Economics, Harvard University, Cambridge, MA, USA.
  • Alver M; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Denmark.
  • Bao Y; Statens Serum Institut, Department of Epidemiology Research, Copenhagen, Denmark.
  • Clark DW; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
  • Day FR; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Furlotte NA; Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, USA.
  • Joshi PK; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
  • Mägi R; Estonian Genome Center, University of Tartu, Tartu, Estonia.
  • Trampush JW; Institute for Social and Economic Research, University of Essex, Colchester, UK.
  • Verma SS; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
  • Wu Y; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
  • Lam M; 23andMe, Inc., Mountain View, CA, USA.
  • Zhao JH; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
  • Zheng Z; Institute of Social and Preventive Medicine, University Hospital of Lausanne, Lausanne, Switzerland.
  • Boardman JD; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
  • Campbell H; 23andMe, Inc., Mountain View, CA, USA.
  • Freese J; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
  • Harris KM; Estonian Genome Center, University of Tartu, Tartu, Estonia.
  • Hayward C; BrainWorkup, LLC, Santa Monica, CA, USA.
  • Herd P; Department of Psychiatry and Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Kumari M; Department of Biomedical and Translational Informatics, Geisinger Health System, Danville, PA, USA.
  • Lencz T; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
  • Luan J; Institute of Mental Health, Singapore, Singapore.
  • Malhotra AK; Genome Institute, Singapore, Singapore.
  • Metspalu A; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
  • Milani L; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
  • Ong KK; The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China.
  • Perry JRB; Department of Sociology, University of Colorado Boulder, Boulder, CO, USA.
Nat Genet ; 50(8): 1112-1121, 2018 07 23.
Article em En | MEDLINE | ID: mdl-30038396
ABSTRACT
Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify 10 independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3% in both men and women, consistent with partial dosage compensation. A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11-13% of the variance in educational attainment and 7-10% of the variance in cognitive performance. This prediction accuracy substantially increases the utility of polygenic scores as tools in research.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Herança Multifatorial Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Genet Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Herança Multifatorial Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Genet Ano de publicação: 2018 Tipo de documento: Article