Gastric carcinoma subsequent to myelodysplastic syndrome with t (1; 19) chromosome translocation: A rare case report and its potential mechanisms.
Medicine (Baltimore)
; 97(30): e11535, 2018 Jul.
Article
em En
| MEDLINE
| ID: mdl-30045276
ABSTRACT
RATIONALE Myelodysplastic syndrome (MDS) is a heterogeneous malignant hematologic disease with median overall survival ranging from six months to more than ten years. Solid tumor rarely occurs in combination with MDS and the underlying pathogenesis and prognostic significance still remain controversial. PATIENT CONCERNS Here we report a relative low risk myelodysplastic syndrome-refractory cytopenia with multilineage dysplasia (MDS-RCMD) patient, with a rare t(1; 19)chromosome translocation. This patient also suffered from gastric carcinoma. DIAGNOSES Gastric carcinoma, Myelodysplastic syndrome with t (1; 19) chromosome translocation. INTERVENTIONS:
This patient received radical operation for gastric carcinoma and erythropoietin infusion.OUTCOMES:
The patient took follow up visits every 2 to 3 months in past years and now he is in stable disease without further treatment. LESSONS We reviewed the mechanism of MDS complicated by solid tumor and concluded the potential mechanisms of this patient. The interactions between potential factors may play a role in oncogenesis which, however, need an in-depth study of its operating mechanism.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
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Translocação Genética
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Síndromes Mielodisplásicas
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Cromossomos Humanos Par 1
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Cromossomos Humanos Par 19
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Anemia Refratária
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Carcinoma
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Eritropoetina
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Gastrectomia
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Prognostic_studies
Limite:
Humans
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Male
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Middle aged
Idioma:
En
Revista:
Medicine (Baltimore)
Ano de publicação:
2018
Tipo de documento:
Article