Pharmacological Inhibition of Soluble Epoxide Hydrolase Ameliorates Chronic Ethanol-Induced Cardiac Fibrosis by Restoring Autophagic Flux.

Zhou, Chi; Huang, Jin; Li, Qing; Zhan, Chenao; He, Ying; Liu, Jinyan; Wen, Zheng; Wang, Dao Wen

Zhou, Chi; Huang, Jin; Li, Qing; Zhan, Chenao; He, Ying; Liu, Jinyan; Wen, Zheng; Wang, Dao Wen.

Afiliação

Zhou C; Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan, China.
Huang J; Division of Hematology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
Li Q; Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan, China.
Zhan C; Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan, China.
He Y; Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan, China.
Liu J; Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan, China.
Wen Z; Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan, China.
Wang DW; Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan, China.

Alcohol Clin Exp Res ; 42(10): 1970-1978, 2018 10.

Article em En | MEDLINE | ID: mdl-30047995

Assuntos

Autofagia/efeitos dos fármacos; Epóxido Hidrolases/antagonistas & inibidores; Etanol/toxicidade; Miocárdio/enzimologia; Compostos de Fenilureia/farmacologia; Piperidinas/farmacologia; Animais; Animais Recém-Nascidos; Autofagia/fisiologia; Células Cultivadas; Epóxido Hidrolases/metabolismo; Etanol/administração & dosagem; Fibrose/induzido quimicamente; Fibrose/tratamento farmacológico; Fibrose/enzimologia; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Miocárdio/patologia; Compostos de Fenilureia/uso terapêutico; Piperidinas/uso terapêutico; Ratos

Palavras-chave

1-Trifluoromethoxyphenyl-3-(1-Propionylpiperidin-4-yl) Urea; Autophagy; Cardiac Fibrosis; Ethanol; Soluble Epoxide Hydrolase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Fenilureia / Piperidinas / Autofagia / Etanol / Epóxido Hidrolases / Miocárdio Limite: Animals Idioma: En Revista: Alcohol Clin Exp Res Ano de publicação: 2018 Tipo de documento: Article

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