Insect-specific viruses: from discovery to potential translational applications.
Curr Opin Virol
; 33: 33-41, 2018 12.
Article
em En
| MEDLINE
| ID: mdl-30048906
ABSTRACT
Over the past decade the scientific community has experienced a new age of virus discovery in arthropods in general, and in insects in particular. Next generation sequencing and advanced bioinformatics tools have provided new insights about insect viromes and viral evolution. In this review, we discuss some high-throughput sequencing technologies used to discover viruses in insects and the challenges raised in data interpretations. Additionally, the discovery of these novel viruses that are considered as insect-specific viruses (ISVs) has gained increasing attention in their potential use as biological agents. As example, we show how the ISV Nhumirim virus was used to reduce West Nile virus transmission when co-infecting the mosquito vector. We also discuss new translational opportunities of using ISVs to limit insect vector competence by using them to interfere with pathogen acquisition, to directly target the insect vector or to confer pathogen resistance by the insect vector.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vírus
/
Interações Hospedeiro-Patógeno
/
Insetos
Limite:
Animals
Idioma:
En
Revista:
Curr Opin Virol
Ano de publicação:
2018
Tipo de documento:
Article