Polymorphism of the precursor for the major surface antigens of Plasmodium falciparum merozoites: studies at the genetic level.
EMBO J
; 4(13B): 3823-9, 1985 Dec 30.
Article
em En
| MEDLINE
| ID: mdl-3004972
ABSTRACT
The gene for the precursor of Plasmodium falciparum merozoite surface antigens has been cloned. The entire sequence of the gene from a Thai isolate of the parasite is reported. It provides evidence for a signal peptide, a region containing short repeating peptides and an anchor sequence. In addition, the 5' end of a Papua New Guinea isolate has been sequenced. Comparison of these and other sequences defines, at the genetic level, a polymorphic region in the protein, and suggests that other parts of the protein are less susceptible to variation. Furthermore it appears that several signal peptides of P. falciparum exhibit extensive sequence homologies.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Plasmodium falciparum
/
Polimorfismo Genético
/
Genes
/
Antígenos de Superfície
Limite:
Animals
Idioma:
En
Revista:
EMBO J
Ano de publicação:
1985
Tipo de documento:
Article