Fingerprints of CNS drug effects: a plasma neuroendocrine reflection of D<sub>2</sub> receptor activation using multi-biomarker pharmacokinetic/pharmacodynamic modelling.

van den Brink, Willem J; van den Berg, Dirk-Jan; Bonsel, Floor E M; Hartman, Robin; Wong, Yin-Cheong; van der Graaf, Piet H; de Lange, Elizabeth C M

Fingerprints of CNS drug effects: a plasma neuroendocrine reflection of D₂ receptor activation using multi-biomarker pharmacokinetic/pharmacodynamic modelling.

van den Brink, Willem J; van den Berg, Dirk-Jan; Bonsel, Floor E M; Hartman, Robin; Wong, Yin-Cheong; van der Graaf, Piet H; de Lange, Elizabeth C M.

Afiliação

van den Brink WJ; Division of Systems Biomedicine and Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands.
van den Berg DJ; Division of Systems Biomedicine and Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands.
Bonsel FEM; Division of Systems Biomedicine and Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands.
Hartman R; Division of Systems Biomedicine and Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands.
Wong YC; Division of Systems Biomedicine and Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands.
van der Graaf PH; Division of Systems Biomedicine and Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands.
de Lange ECM; Certara QSP, Canterbury Innovation House, Canterbury, UK.

Br J Pharmacol ; 175(19): 3832-3843, 2018 10.

Article em En | MEDLINE | ID: mdl-30051461

Assuntos

Fármacos do Sistema Nervoso Central/farmacocinética; Hormônio Liberador da Corticotropina/sangue; Modelos Biológicos; Quimpirol/farmacocinética; Receptores de Dopamina D2/agonistas; Animais; Biomarcadores/sangue; Biomarcadores/metabolismo; Fármacos do Sistema Nervoso Central/administração & dosagem; Fármacos do Sistema Nervoso Central/sangue; Hormônio Liberador da Corticotropina/metabolismo; Hormônios/sangue; Hormônios/metabolismo; Injeções Intravenosas; Injeções Subcutâneas; Masculino; Neuropeptídeos/sangue; Neuropeptídeos/metabolismo; Quimpirol/administração & dosagem; Quimpirol/sangue; Ratos; Ratos Wistar; Receptores de Dopamina D2/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hormônio Liberador da Corticotropina / Fármacos do Sistema Nervoso Central / Receptores de Dopamina D2 / Quimpirol / Modelos Biológicos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Br J Pharmacol Ano de publicação: 2018 Tipo de documento: Article

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