Levels of Pro and Anti-inflammatory Citokynes and C-Reactive Protein in Patients with Chronic Periodontitis Submitted to Nonsurgical Periodontal Treatment
Asian Pac J Cancer Prev
; 19(7): 1927-1933, 2018 Jul 27.
Article
em En
| MEDLINE
| ID: mdl-30051674
ABSTRACT
Aim:
to compare the levels of IFN-γ, TGF-ß and C-reactive protein (CRP) in healthy patients (HP) and chronic periodontitis patients (CP) before and seven days after the last session of Non-Surgical Periodontal Treatment (NSPT). Materials andMethods:
40 subjects were divided into two groups healthy (n= 20), and with chronic periodontitis (n = 20). Serum and gingival crevicular fluid (GCF) were collected from each patient and quantified for IFN-γ, TGF-ß and CRP using the enzyme-linked immunosorbent assay (ELISA).Results:
IFN-γ was found to be higher in the GCF of the CP group before NSPT in relation to the HP group (p<0.05), and it had significant higher levels after seven days of NSPT (p<0.05). The levels of TGF-ß in the GCF of CP patients before NSPT were significantly higher when compared to HP (p<0.05), but they decreased after seven days of NSPT (p>0.05). Serum CRP levels did not show statistical difference between CP and HP before or after NSPT.Conclusion:
Therefore, our results demonstrated for the first time that NSPT causes early exacerbation of the immune response at the local level represented by increased levels of IFN-γ and decreased levels of TGF-ß in the gingival crevicular fluid after seven days of treatment.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteína C-Reativa
/
Biomarcadores
/
Fator de Crescimento Transformador beta
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Líquido do Sulco Gengival
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Periodontite Crônica
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Asian Pac J Cancer Prev
Ano de publicação:
2018
Tipo de documento:
Article