Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic ß-cells.

Thomsen, Soren K; Raimondo, Anne; Hastoy, Benoit; Sengupta, Shahana; Dai, Xiao-Qing; Bautista, Austin; Censin, Jenny; Payne, Anthony J; Umapathysivam, Mahesh M; Spigelman, Aliya F; Barrett, Amy; Groves, Christopher J; Beer, Nicola L; Manning Fox, Jocelyn E; McCarthy, Mark I; Clark, Anne; Mahajan, Anubha; Rorsman, Patrik; MacDonald, Patrick E; Gloyn, Anna L

Thomsen, Soren K; Raimondo, Anne; Hastoy, Benoit; Sengupta, Shahana; Dai, Xiao-Qing; Bautista, Austin; Censin, Jenny; Payne, Anthony J; Umapathysivam, Mahesh M; Spigelman, Aliya F; Barrett, Amy; Groves, Christopher J; Beer, Nicola L; Manning Fox, Jocelyn E; McCarthy, Mark I; Clark, Anne; Mahajan, Anubha; Rorsman, Patrik; MacDonald, Patrick E; Gloyn, Anna L.

Afiliação

Thomsen SK; Oxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Oxford, UK.
Raimondo A; Vertex Pharmaceuticals Europe Ltd, Milton Park, Abingdon, UK.
Hastoy B; Oxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Oxford, UK.
Sengupta S; National Health and Medical Research Council, Canberra, Australia.
Dai XQ; Oxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Oxford, UK.
Bautista A; Oxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Oxford, UK.
Censin J; MRC Harwell Institute, Harwell Campus, Oxfordshire, UK.
Payne AJ; Department of Pharmacology and Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.
Umapathysivam MM; Department of Pharmacology and Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.
Spigelman AF; Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.
Barrett A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Groves CJ; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Beer NL; Oxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Oxford, UK.
Manning Fox JE; Department of Pharmacology and Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.
McCarthy MI; Oxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Oxford, UK.
Clark A; Oxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Oxford, UK.
Mahajan A; Oxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Oxford, UK.
Rorsman P; Department of Pharmacology and Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.
MacDonald PE; Oxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Oxford, UK.
Gloyn AL; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.

Nat Genet ; 50(8): 1122-1131, 2018 08.

Article em En | MEDLINE | ID: mdl-30054598

Assuntos

Amidina-Liases/genética; Diabetes Mellitus Tipo 2/genética; Secreção de Insulina/genética; Células Secretoras de Insulina/patologia; Oxigenases de Função Mista/genética; Alelos; Animais; Linhagem Celular; Predisposição Genética para Doença; Células HEK293; Humanos; Insulina/genética; Camundongos; Polimorfismo de Nucleotídeo Único

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Amidina-Liases / Diabetes Mellitus Tipo 2 / Células Secretoras de Insulina / Secreção de Insulina / Oxigenases de Função Mista Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Nat Genet Ano de publicação: 2018 Tipo de documento: Article

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