Incidence, prevalence and clinical outcome of anaemia in inflammatory bowel disease: a population-based cohort study.
Aliment Pharmacol Ther
; 48(6): 638-645, 2018 09.
Article
em En
| MEDLINE
| ID: mdl-30069892
ABSTRACT
BACKGROUND:
The incidence and short-term outcome of anaemia in inflammatory bowel disease (IBD) are largely unknown.AIM:
To determine the incidence, prevalence and clinical outcome of anaemia in terms of resolution of anaemia within 12 months. We also planned to assess risk factors for anaemia in IBD.METHODS:
A random sample of 342 patients was obtained from the population-based IBD cohort of Örebro University Hospital, Sweden, consisting of 1405 patients diagnosed between 1963 and 2010. Haemoglobin measurements recorded from 1 January 2011 to 31 December 2013 were extracted from the Clinical Chemistry data system.RESULTS:
In Crohn's disease, the incidence rate of anaemia was 19.3 (95% CI 15.4-23.7) per 100 person-years and the prevalence was 28.7% (CI 22.0-36.2), compared with 12.9 (CI 9.8-16.5) and 16.5% (CI 11.2-22.9) for ulcerative colitis. Crohn's disease was associated with an increased incidence (OR = 1.60; CI 1.02-2.51) and prevalence of anaemia (OR = 2.04; CI 1.20-3.46) compared to ulcerative colitis. Stricturing disease phenotype in Crohn's disease (HR = 2.59; CI 1.00-6.79) and extensive disease in ulcerative colitis (HR = 2.40; CI 1.10-5.36) were associated with an increased risk of anaemia. Despite a higher probability of receiving specific therapy within 3 months from the diagnosis of anaemia, Crohn's disease patients had a worse outcome in terms of resolution of anaemia within 12 months (56% vs 75%; P = 0.03).CONCLUSIONS:
Anaemia is a common manifestation of IBD even beyond the first years after the diagnosis of IBD. Crohn's disease is associated with both an increased risk and a worse outcome.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Inflamatórias Intestinais
/
Anemia
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Aliment Pharmacol Ther
Ano de publicação:
2018
Tipo de documento:
Article