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A novel inhibitor of ADAM17 sensitizes colorectal cancer cells to 5-Fluorouracil by reversing Notch and epithelial-mesenchymal transition in vitro and in vivo.
Li, Dan-Dan; Zhao, Chang-Hao; Ding, Huai-Wei; Wu, Qiong; Ren, Tian-Shu; Wang, Jian; Chen, Cong-Qin; Zhao, Qing-Chun.
Afiliação
  • Li DD; Department of Pharmacy, General Hospital of Shenyang Military Area Command, Shenyang, China.
  • Zhao CH; Department of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, China.
  • Ding HW; College of Pharmacy, The Heilongjiang University of Traditional Chinese Medicine, Heilongjiang, China.
  • Wu Q; Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
  • Ren TS; Department of Pharmacy, General Hospital of Shenyang Military Area Command, Shenyang, China.
  • Wang J; Department of Pharmacy, General Hospital of Shenyang Military Area Command, Shenyang, China.
  • Chen CQ; Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
  • Zhao QC; Department of Pharmacy, General Hospital of Shenyang Military Area Command, Shenyang, China.
Cell Prolif ; 51(5): e12480, 2018 Oct.
Article em En | MEDLINE | ID: mdl-30069943

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Receptores Notch / Transição Epitelial-Mesenquimal / Fluoruracila / Proteína ADAM17 / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Cell Prolif Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Receptores Notch / Transição Epitelial-Mesenquimal / Fluoruracila / Proteína ADAM17 / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Cell Prolif Ano de publicação: 2018 Tipo de documento: Article