KDM8/JMJD5 as a dual coactivator of AR and PKM2 integrates AR/EZH2 network and tumor metabolism in CRPC.

Wang, Hung-Jung; Pochampalli, Mamata; Wang, Ling-Yu; Zou, June X; Li, Pei-Shan; Hsu, Sheng-Chieh; Wang, Bi-Juan; Huang, Shih-Han; Yang, Ping; Yang, Joy C; Chu, Cheng-Ying; Hsieh, Chia-Ling; Sung, Shian-Ying; Li, Chien-Feng; Tepper, Clifford G; Ann, David K; Gao, Allen C; Evans, Christopher P; Izumiya, Yoshihiro; Chuu, Chi-Pin; Wang, Wen-Ching; Chen, Hong-Wu; Kung, Hsing-Jien

Wang, Hung-Jung; Pochampalli, Mamata; Wang, Ling-Yu; Zou, June X; Li, Pei-Shan; Hsu, Sheng-Chieh; Wang, Bi-Juan; Huang, Shih-Han; Yang, Ping; Yang, Joy C; Chu, Cheng-Ying; Hsieh, Chia-Ling; Sung, Shian-Ying; Li, Chien-Feng; Tepper, Clifford G; Ann, David K; Gao, Allen C; Evans, Christopher P; Izumiya, Yoshihiro; Chuu, Chi-Pin; Wang, Wen-Ching; Chen, Hong-Wu; Kung, Hsing-Jien.

Afiliação

Wang HJ; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35053, Miaoli County, Taiwan. hjwang@nhri.org.tw.
Pochampalli M; Institute of Molecular and Genomic Medicine, National Health Research Institutes, 35053, Miaoli County, Taiwan. hjwang@nhri.org.tw.
Wang LY; Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, CA, 95817, USA.
Zou JX; Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, CA, 95817, USA.
Li PS; Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, CA, 95817, USA.
Hsu SC; Institute of Molecular and Genomic Medicine, National Health Research Institutes, 35053, Miaoli County, Taiwan.
Wang BJ; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35053, Miaoli County, Taiwan.
Huang SH; Institute of Biotechnology, National Tsing-Hua University, 30035, Hsinchu, Taiwan.
Yang P; Institute of Cellular and System Medicine, National Health Research Institutes, 35053, Miaoli County, Taiwan.
Yang JC; Institute of Cellular and System Medicine, National Health Research Institutes, 35053, Miaoli County, Taiwan.
Chu CY; Department of Urology, School of Medicine, University of California, Davis, CA, 95817, USA.
Hsieh CL; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
Sung SY; Department of Urology, School of Medicine, University of California, Davis, CA, 95817, USA.
Li CF; Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei City, Taiwan.
Tepper CG; Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei City, Taiwan.
Ann DK; Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei City, Taiwan.
Gao AC; National Institute of Cancer Research, National Health Research Institutes, 35053, Miaoli County, Taiwan.
Evans CP; Department of Urology, School of Medicine, University of California, Davis, CA, 95817, USA.
Izumiya Y; Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei City, Taiwan.
Chuu CP; Department of Molecular Pharmacology, Beckman Research Institute, City of Hope, Duarte, CA, USA.
Wang WC; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35053, Miaoli County, Taiwan.
Chen HW; Department of Urology, School of Medicine, University of California, Davis, CA, 95817, USA.
Kung HJ; Department of Urology, School of Medicine, University of California, Davis, CA, 95817, USA.

Oncogene ; 38(1): 17-32, 2019 01.

Article em En | MEDLINE | ID: mdl-30072740

Assuntos

Adenocarcinoma/metabolismo; Proteínas de Transporte/metabolismo; Regulação Neoplásica da Expressão Gênica; Histona Desmetilases/fisiologia; Proteínas de Membrana/metabolismo; Proteínas de Neoplasias/fisiologia; Neoplasias de Próstata Resistentes à Castração/metabolismo; Receptores Androgênicos/metabolismo; Hormônios Tireóideos/metabolismo; ATPases Associadas a Diversas Atividades Celulares/fisiologia; Transporte Ativo do Núcleo Celular; Adenocarcinoma/patologia; Animais; Benzamidas; Linhagem Celular Tumoral; Proteínas de Ligação a DNA/fisiologia; Proteína Potenciadora do Homólogo 2 de Zeste/antagonistas & inibidores; Proteína Potenciadora do Homólogo 2 de Zeste/biossíntese; Proteína Potenciadora do Homólogo 2 de Zeste/genética; Técnicas de Silenciamento de Genes; Glicólise/genética; Xenoenxertos; Histona Desmetilases/biossíntese; Histona Desmetilases/genética; Humanos; Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo; Masculino; Camundongos Nus; Proteínas de Neoplasias/antagonistas & inibidores; Proteínas de Neoplasias/biossíntese; Proteínas de Neoplasias/genética; Nitrilas; Feniltioidantoína/análogos & derivados; Feniltioidantoína/farmacologia; Feniltioidantoína/uso terapêutico; Neoplasias de Próstata Resistentes à Castração/patologia; Mapeamento de Interação de Proteínas; RNA Interferente Pequeno/genética; Receptores Androgênicos/genética; Proteínas de Ligação a Hormônio da Tireoide

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hormônios Tireóideos / Adenocarcinoma / Proteínas de Transporte / Receptores Androgênicos / Regulação Neoplásica da Expressão Gênica / Histona Desmetilases / Neoplasias de Próstata Resistentes à Castração / Proteínas de Membrana / Proteínas de Neoplasias Idioma: En Revista: Oncogene Ano de publicação: 2019 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google