Molecular Imaging in Diagnosis of Tumor-induced Osteomalacia.
Curr Probl Diagn Radiol
; 48(4): 379-386, 2019.
Article
em En
| MEDLINE
| ID: mdl-30078476
ABSTRACT
Tumor induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by overproduction of fibroblast growth factor 23 (FGF23) secreted by benign mesenchymal neoplasm. Due to its nonspecific clinical presentation or lack of awareness, the diagnosis of TIO is often significantly delayed resulting in patients' prolonged physical suffering or psychological distress. Successful detection or complete surgical resection of the causative tumor typically leads to rapid resolution of symptoms or reversal of biochemical imbalance. Nuclear medicine and molecular imaging have been playing a promising role as the first-line imaging modalities in the diagnosis and localization of occult FGF23 secreting mesenchymal tumor, especially with the emerging whole-body, head-to-toe Ga68-DOTATATE PET/CT technique. Combined focused diagnostic CT and/or MRI are imperative for accurate delineation of tumor and surgical guidance.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Intensificação de Imagem Radiográfica
/
Imagem Molecular
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Fatores de Crescimento de Fibroblastos
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Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada
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Neoplasias de Tecido Conjuntivo
Tipo de estudo:
Diagnostic_studies
/
Guideline
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Curr Probl Diagn Radiol
Ano de publicação:
2019
Tipo de documento:
Article