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Cycloartane triterpenoid (23R, 24E)-23-acetoxymangiferonic acid inhibited proliferation and migration in B16-F10 melanoma via MITF downregulation caused by inhibition of both ß-catenin and c-Raf-MEK1-ERK signaling axis.
Kaneda, Toshio; Matsumoto, Misaki; Sotozono, Yayoi; Fukami, Satoshi; Nugroho, Alfarius Eko; Hirasawa, Yusuke; Hamid A, Hadi A; Morita, Hiroshi.
Afiliação
  • Kaneda T; Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo, 142-8501, Japan.
  • Matsumoto M; Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo, 142-8501, Japan.
  • Sotozono Y; Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo, 142-8501, Japan.
  • Fukami S; Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo, 142-8501, Japan.
  • Nugroho AE; Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo, 142-8501, Japan.
  • Hirasawa Y; Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo, 142-8501, Japan.
  • Hamid A HA; Department of Chemistry, Faculty of Science, University Malaya, 50603, Kuala Lumpur, Malaysia.
  • Morita H; Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo, 142-8501, Japan. moritah@hoshi.ac.jp.
J Nat Med ; 73(1): 47-58, 2019 Jan.
Article em En | MEDLINE | ID: mdl-30084054
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Melanoma Experimental / Garcinia / Quinases raf / Beta Catenina / Fator de Transcrição Associado à Microftalmia Limite: Humans Idioma: En Revista: J Nat Med Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Melanoma Experimental / Garcinia / Quinases raf / Beta Catenina / Fator de Transcrição Associado à Microftalmia Limite: Humans Idioma: En Revista: J Nat Med Ano de publicação: 2019 Tipo de documento: Article