Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma.
Nat Commun
; 9(1): 3209, 2018 08 10.
Article
em En
| MEDLINE
| ID: mdl-30097565
ABSTRACT
Glaucoma is the most prevalent neurodegenerative disease and a leading cause of blindness worldwide. The mechanisms causing glaucomatous neurodegeneration are not fully understood. Here we show, using mice deficient in T and/or B cells and adoptive cell transfer, that transient elevation of intraocular pressure (IOP) is sufficient to induce T-cell infiltration into the retina. This T-cell infiltration leads to a prolonged phase of retinal ganglion cell degeneration that persists after IOP returns to a normal level. Heat shock proteins (HSP) are identified as target antigens of T-cell responses in glaucomatous mice and human glaucoma patients. Furthermore, retina-infiltrating T cells cross-react with human and bacterial HSPs; mice raised in the absence of commensal microflora do not develop glaucomatous T-cell responses or the associated neurodegeneration. These results provide compelling evidence that glaucomatous neurodegeneration is mediated in part by T cells that are pre-sensitized by exposure to commensal microflora.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
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Glaucoma
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Microbiota
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Degeneração Neural
Limite:
Animals
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Female
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Humans
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Male
Idioma:
En
Revista:
Nat Commun
Ano de publicação:
2018
Tipo de documento:
Article