lncRNA GHET1 down-regulation suppresses the cell activities of glioma.
Cancer Biomark
; 23(1): 9-22, 2018.
Article
em En
| MEDLINE
| ID: mdl-30103301
ABSTRACT
Long noncoding RNAs (lncRNAs) are emerging as new modulators in cancer origination and progression. The previous study found lncRNA gastric carcinoma highly expressed transcript 1 (GHET1) was significantly up-regulation in the gastric cancer. In our present study, we studied the GHET1 expression in glioma and its effects to biological activities of glioma in vitro and vivo studies. In the clinical analysis, the results were shown that lncRNA GHET1 was significantly up-regulation and the Numb protein expression was significantly down-regulation in glioma tissues. In vitro and vivo studies, the results were shown that lncRNA GHET1 knock-down had effects to inhibit biological activities by regulation Numb and down-stream genes P53 and MMP2/9. The results suggested that GHET1 is a novel tumor oncogene by Numb in glioma. LncRNA GHET1 may serve as a potential biomarker and therapeutic target for glioma.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biomarcadores Tumorais
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Proliferação de Células
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RNA Longo não Codificante
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Glioma
Limite:
Animals
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Female
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Humans
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Male
Idioma:
En
Revista:
Cancer Biomark
Ano de publicação:
2018
Tipo de documento:
Article