Chemical Synthesis of Rare, Deoxy-Amino Sugars Containing Bacterial Glycoconjugates as Potential Vaccine Candidates.
Molecules
; 23(8)2018 Aug 10.
Article
em En
| MEDLINE
| ID: mdl-30103434
ABSTRACT
Bacteria often contain rare deoxy amino sugars which are absent in the host cells. This structural difference can be harnessed for the development of vaccines. Over the last fifteen years, remarkable progress has been made toward the development of novel and efficient protocols for obtaining the rare sugar building blocks and their stereoselective assembly to construct conjugation ready bacterial glycans. In this review, we discuss the total synthesis of a variety of rare sugar containing bacterial glycoconjugates which are potential vaccine candidates.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bactérias
/
Glicoconjugados
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Vacinas Bacterianas
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Amino Açúcares
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Antígenos de Bactérias
Limite:
Animals
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Humans
Idioma:
En
Revista:
Molecules
Ano de publicação:
2018
Tipo de documento:
Article