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US28: HCMV's Swiss Army Knife.
Krishna, Benjamin A; Miller, William E; O'Connor, Christine M.
Afiliação
  • Krishna BA; Genomic Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA. krishnb2@ccf.org.
  • Miller WE; Department of Molecular Genetics, Biochemistry, & Microbiology, University of Cincinnati, Cincinnati, OH 45267, USA. millerwe@ucmail.uc.edu.
  • O'Connor CM; Genomic Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA. oconnoc6@ccf.org.
Viruses ; 10(8)2018 08 20.
Article em En | MEDLINE | ID: mdl-30127279
US28 is one of four G protein coupled receptors (GPCRs) encoded by human cytomegalovirus (HCMV). The US28 protein (pUS28) is a potent signaling molecule that alters a variety of cellular pathways that ultimately alter the host cell environment. This viral GPCR is expressed not only in the context of lytic replication but also during viral latency, highlighting its multifunctional properties. pUS28 is a functional GPCR, and its manipulation of multiple signaling pathways likely impacts HCMV pathogenesis. Herein, we will discuss the impact of pUS28 on both lytic and latent infection, pUS28-mediated signaling and its downstream consequences, and the influence this viral GPCR may have on disease states, including cardiovascular disease and cancer. We will also discuss the potential for and progress towards exploiting pUS28 as a novel therapeutic to combat HCMV.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Virais / Doenças Cardiovasculares / Regulação Viral da Expressão Gênica / Infecções por Citomegalovirus / Receptores de Quimiocinas / Citomegalovirus / Interações Hospedeiro-Patógeno / Neoplasias Limite: Humans Idioma: En Revista: Viruses Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Virais / Doenças Cardiovasculares / Regulação Viral da Expressão Gênica / Infecções por Citomegalovirus / Receptores de Quimiocinas / Citomegalovirus / Interações Hospedeiro-Patógeno / Neoplasias Limite: Humans Idioma: En Revista: Viruses Ano de publicação: 2018 Tipo de documento: Article