Rapamycin rescues BMP mediated midline craniosynostosis phenotype through reduction of mTOR signaling in a mouse model.

Kramer, Kaitrin; Yang, Jingwen; Swanson, W Benton; Hayano, Satoru; Toda, Masako; Pan, Haichun; Kim, Jin Koo; Krebsbach, Paul H; Mishina, Yuji

Kramer, Kaitrin; Yang, Jingwen; Swanson, W Benton; Hayano, Satoru; Toda, Masako; Pan, Haichun; Kim, Jin Koo; Krebsbach, Paul H; Mishina, Yuji.

Afiliação

Kramer K; Department of Biologic & Materials Sciences, School of Dentistry, University Michigan, Ann Arbor, Michigan, 48109.
Yang J; Department of Biologic & Materials Sciences, School of Dentistry, University Michigan, Ann Arbor, Michigan, 48109.
Hayano S; Department of Biologic & Materials Sciences, School of Dentistry, University Michigan, Ann Arbor, Michigan, 48109.
Toda M; Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Pan H; Department of Biologic & Materials Sciences, School of Dentistry, University Michigan, Ann Arbor, Michigan, 48109.
Kim JK; Department of Biologic & Materials Sciences, School of Dentistry, University Michigan, Ann Arbor, Michigan, 48109.
Krebsbach PH; Department of Biologic & Materials Sciences, School of Dentistry, University Michigan, Ann Arbor, Michigan, 48109.
Mishina Y; Los Angeles School of Dentistry, Section of Periodontics, University of California, Los Angeles, California, 90095.

Genesis ; 56(6-7): e23220, 2018 06.

Article em En | MEDLINE | ID: mdl-30134066

Assuntos

Craniossinostoses/genética; Sirolimo/farmacologia; Serina-Treonina Quinases TOR/efeitos dos fármacos; Animais; Proteínas Morfogenéticas Ósseas/efeitos dos fármacos; Proteínas Morfogenéticas Ósseas/fisiologia; Suturas Cranianas/embriologia; Craniossinostoses/tratamento farmacológico; Modelos Animais de Doenças; Camundongos; Camundongos Endogâmicos C57BL; Crista Neural/metabolismo; Fenótipo; Transdução de Sinais/efeitos dos fármacos; Sirolimo/metabolismo; Crânio/embriologia

Palavras-chave

BMP Smad signaling; craniosynostosis; mTOR; neural crest cells; suture

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sirolimo / Craniossinostoses / Serina-Treonina Quinases TOR Limite: Animals Idioma: En Revista: Genesis Ano de publicação: 2018 Tipo de documento: Article

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