The possible origin of human adenovirus type 3: Evidence of natural genetic recombination between human and simian adenovirus.
Infect Genet Evol
; 65: 380-384, 2018 11.
Article
em En
| MEDLINE
| ID: mdl-30144567
ABSTRACT
We determined a complete genome sequence of the Korean field strain, KUMC-62, of human adenovirus type 3 (HAdV-3) and performed comparative genome analyses. Interestingly HAdV-3 has a distinct genomic sequence for the fiber CDS region on average 62.46% of nucleotide sequence identity to other types of HAdV-B1, while remaining genomic region of HAdV-3 is very similar (on average 95.71% of nucleotide sequence identity) to other types of HAdV-B1. The blast results showed that the fiber CDS region of HAdV-3 exhibited the highest nucleotide sequence identity with that of simian adenovirus type 32 (SAdV-32), except other strains of HAdV-3. In the Simplot analysis, a potential recombination event was detected between HAdV-7 and SAdV-32, which might have created HAdV-3 in the past. These findings suggest that HAdV-3 highly likely was created by a natural inter-species recombination event between human and non-human primate AdVs.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Filogenia
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Infecções por Adenovirus Humanos
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Adenovírus Humanos
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Adenovirus dos Símios
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Genoma Viral
Limite:
Animals
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Humans
Idioma:
En
Revista:
Infect Genet Evol
Ano de publicação:
2018
Tipo de documento:
Article