PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma.

Liu, Tianrun; Ma, Wenjuan; Xu, Haineng; Huang, Menggui; Zhang, Duo; He, Zhenqiang; Zhang, Lin; Brem, Steven; O'Rourke, Donald M; Gong, Yanqing; Mou, Yonggao; Zhang, Zhenfeng; Fan, Yi

Liu, Tianrun; Ma, Wenjuan; Xu, Haineng; Huang, Menggui; Zhang, Duo; He, Zhenqiang; Zhang, Lin; Brem, Steven; O'Rourke, Donald M; Gong, Yanqing; Mou, Yonggao; Zhang, Zhenfeng; Fan, Yi.

Afiliação

Liu T; Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Ma W; Division of Head and Neck Surgery, Department of Otorhinolaryngology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510655, China.
Xu H; Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Huang M; Department of Medical Oncology, State Key Laboratory of Oncology in South China & Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.
Zhang D; Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
He Z; Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Zhang L; Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Brem S; Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
O'Rourke DM; Department of Neurosurgery, State Key Laboratory of Oncology in South China & Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.
Gong Y; Department of Obstetrics & Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Mou Y; Department of Neurosurgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Zhang Z; Department of Neurosurgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Fan Y; Division of Human Genetics and Translational Medicine, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.

Nat Commun ; 9(1): 3439, 2018 08 27.

Article em En | MEDLINE | ID: mdl-30150753

Assuntos

Glioblastoma/tratamento farmacológico; Glioblastoma/metabolismo; Fator de Crescimento Derivado de Plaquetas/metabolismo; Receptor 2 de Fatores de Crescimento do Endotélio Vascular/metabolismo; Animais; Linhagem Celular Tumoral; Proliferação de Células; Células Cultivadas; Galinhas; Imunoprecipitação da Cromatina; Células Endoteliais/efeitos dos fármacos; Células Endoteliais/metabolismo; Citometria de Fluxo; Imunofluorescência; Humanos; Immunoblotting; Camundongos; Camundongos Knockout; NF-kappa B/metabolismo; Fator de Crescimento Derivado de Plaquetas/antagonistas & inibidores; Reação em Cadeia da Polimerase em Tempo Real; Fatores de Transcrição da Família Snail; Receptor 2 de Fatores de Crescimento do Endotélio Vascular/antagonistas & inibidores

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Crescimento Derivado de Plaquetas / Glioblastoma / Receptor 2 de Fatores de Crescimento do Endotélio Vascular Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Nat Commun Ano de publicação: 2018 Tipo de documento: Article

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