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Biotransformation of Finerenone, a Novel Nonsteroidal Mineralocorticoid Receptor Antagonist, in Dogs, Rats, and Humans, In Vivo and In Vitro.
Gerisch, Michael; Heinig, Roland; Engelen, Anna; Lang, Dieter; Kolkhof, Peter; Radtke, Martin; Platzek, Johannes; Lovis, Kai; Rohde, Gabriele; Schwarz, Thomas.
Afiliação
  • Gerisch M; Drug Metabolism and Pharmacokinetics (M.G., A.E., D.L., M.R., G.R., T.S.), Clinical Sciences (R.H.), Cardiology Research (P.K.), and Pharmaceutical Development (J.P., K.L.), Bayer AG, Wuppertal, Germany michael.gerisch@bayer.com.
  • Heinig R; Drug Metabolism and Pharmacokinetics (M.G., A.E., D.L., M.R., G.R., T.S.), Clinical Sciences (R.H.), Cardiology Research (P.K.), and Pharmaceutical Development (J.P., K.L.), Bayer AG, Wuppertal, Germany.
  • Engelen A; Drug Metabolism and Pharmacokinetics (M.G., A.E., D.L., M.R., G.R., T.S.), Clinical Sciences (R.H.), Cardiology Research (P.K.), and Pharmaceutical Development (J.P., K.L.), Bayer AG, Wuppertal, Germany.
  • Lang D; Drug Metabolism and Pharmacokinetics (M.G., A.E., D.L., M.R., G.R., T.S.), Clinical Sciences (R.H.), Cardiology Research (P.K.), and Pharmaceutical Development (J.P., K.L.), Bayer AG, Wuppertal, Germany.
  • Kolkhof P; Drug Metabolism and Pharmacokinetics (M.G., A.E., D.L., M.R., G.R., T.S.), Clinical Sciences (R.H.), Cardiology Research (P.K.), and Pharmaceutical Development (J.P., K.L.), Bayer AG, Wuppertal, Germany.
  • Radtke M; Drug Metabolism and Pharmacokinetics (M.G., A.E., D.L., M.R., G.R., T.S.), Clinical Sciences (R.H.), Cardiology Research (P.K.), and Pharmaceutical Development (J.P., K.L.), Bayer AG, Wuppertal, Germany.
  • Platzek J; Drug Metabolism and Pharmacokinetics (M.G., A.E., D.L., M.R., G.R., T.S.), Clinical Sciences (R.H.), Cardiology Research (P.K.), and Pharmaceutical Development (J.P., K.L.), Bayer AG, Wuppertal, Germany.
  • Lovis K; Drug Metabolism and Pharmacokinetics (M.G., A.E., D.L., M.R., G.R., T.S.), Clinical Sciences (R.H.), Cardiology Research (P.K.), and Pharmaceutical Development (J.P., K.L.), Bayer AG, Wuppertal, Germany.
  • Rohde G; Drug Metabolism and Pharmacokinetics (M.G., A.E., D.L., M.R., G.R., T.S.), Clinical Sciences (R.H.), Cardiology Research (P.K.), and Pharmaceutical Development (J.P., K.L.), Bayer AG, Wuppertal, Germany.
  • Schwarz T; Drug Metabolism and Pharmacokinetics (M.G., A.E., D.L., M.R., G.R., T.S.), Clinical Sciences (R.H.), Cardiology Research (P.K.), and Pharmaceutical Development (J.P., K.L.), Bayer AG, Wuppertal, Germany.
Drug Metab Dispos ; 46(11): 1546-1555, 2018 11.
Article em En | MEDLINE | ID: mdl-30171161
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biotransformação / Antagonistas de Receptores de Mineralocorticoides / Naftiridinas Tipo de estudo: Clinical_trials Limite: Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Drug Metab Dispos Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biotransformação / Antagonistas de Receptores de Mineralocorticoides / Naftiridinas Tipo de estudo: Clinical_trials Limite: Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Drug Metab Dispos Ano de publicação: 2018 Tipo de documento: Article