Hexaricins, Pradimicin-like Polyketides from a Marine Sediment-Derived Streptosporangium sp. and Their Antioxidant Effects.
J Nat Prod
; 81(9): 2069-2074, 2018 09 28.
Article
em En
| MEDLINE
| ID: mdl-30178674
ABSTRACT
Seven pradimicin-like polyketides were isolated from the dichloromethane extract of the marine sediment-derived Streptosporangium sp. CGMCC 4.7309, including five new hexaricins, D-H (1-5), and known hexaricins A (6) and C (7). Their structures were determined by HRESIMS, 1D and 2D NMR, and other spectroscopic analyses. The absolute configurations of compounds 1-5 were determined on the basis of circular dichroism and specific rotation data. All isolated compounds 1-7 were tested for their antioxidant capacities by DPPH⢠scavenging, â¢OH scavenging, and â¢O2Ì
scavenging assays. Compounds 3 and 4 displayed stronger antioxidant activities than the positive control ( tert-butylhydroquinone). The relationship between structure and antioxidant activity is discussed. These compounds could be effective natural antioxidants with considerable pharmaceutical value.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Actinobacteria
/
Sedimentos Geológicos
/
Policetídeos
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Antioxidantes
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2018
Tipo de documento:
Article