Incomplete base excision repair contributes to cell death from antibiotics and other stresses.
DNA Repair (Amst)
; 71: 108-117, 2018 11.
Article
em En
| MEDLINE
| ID: mdl-30181041
ABSTRACT
Numerous lethal stresses in bacteria including antibiotics, thymineless death, and MalE-LacZ expression trigger an increase in the production of reactive oxygen species. This results in the oxidation of the nucleotide pool by radicals produced by Fenton chemistry. Following the incorporation of these oxidized nucleotides into the genome, the cell's unsuccessful attempt to repair these lesions through base excision repair (BER) contributes causally to the lethality of these stresses. We review the evidence for this phenomenon of incomplete BER-mediated cell death and discuss how better understanding this pathway could contribute to the development of new antibiotics.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dano ao DNA
/
Morte Celular
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Espécies Reativas de Oxigênio
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Reparo do DNA
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Antibacterianos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
DNA Repair (Amst)
Ano de publicação:
2018
Tipo de documento:
Article