An integrated strategy for identifying new targets and inferring the mechanism of action: taking rhein as an example.

Sun, Hao; Shen, Yiting; Luo, Guangwen; Cai, Yuepiao; Xiang, Zheng

Sun, Hao; Shen, Yiting; Luo, Guangwen; Cai, Yuepiao; Xiang, Zheng.

Afiliação

Sun H; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, China.
Shen Y; Pharmacy Department, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, Zhejiang, China.
Luo G; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, China.
Cai Y; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, China.
Xiang Z; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, China. ypcai@wmu.edu.cn.

BMC Bioinformatics ; 19(1): 315, 2018 Sep 06.

Article em En | MEDLINE | ID: mdl-30189851

Assuntos

Antraquinonas/farmacologia; Biologia Computacional/métodos; Descoberta de Drogas/métodos; Inibidores Enzimáticos/farmacologia; Farmacologia/métodos; Mapas de Interação de Proteínas; Proteínas/metabolismo; Humanos

Palavras-chave

Enrichment analysis; Ligand-protein docking; Network analysis; Rhein; SPR; Target identification

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Farmacologia / Proteínas / Antraquinonas / Biologia Computacional / Inibidores Enzimáticos / Descoberta de Drogas / Mapas de Interação de Proteínas Limite: Humans Idioma: En Revista: BMC Bioinformatics Ano de publicação: 2018 Tipo de documento: Article

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